Dandruff/Seborrheic dermatitis Triad Model

A model for the etiology of dandruff/seborrheic dermatitis describing the convergence of three factors: 1) sebum, which provides the substrate for Malassezia growth, 2) Malassezia, which metabolizes sebum and releases irritating unsaturated fatty acids and 3) individual susceptibility to the penetration of the fatty acids, which is associated with the hyperproliferative state of the scalp epidermis in dandruff/seborrheic dermatitis areas.

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